The interaction term in a moderated regression is either significant or it's not. When it comes to simple slopes, however, you can test whether each single simple slope differs significantly from zero. These significance tests are dependent on which value of the moderator you probe the slope.
Using +/- 1 SD simply is just a convention - but it makes sense. It shows the slopes of two hypothetical groups, one 1 SD below the mean (which equals a percentage rank of 16% under the assumption of normality) and one 1 SD above the mean (PR = 84%). If you take 2 SD it would characterize groups at PR = 2% and 98% - these are rather extreme values and do not characterize a typical member of the sample.
So I would say it is not OK to use 2 SD, unless you have a good argument why you want to show simple slopes for very extreme groups.