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My question may be very basic but I hope that you can help me. I have got two groups (A and B). I am measuring two continuous biological measures (X and Y) which are significantly positively correlated. Theoretically it is clear that X can influence Y but not vice versa. Y has been measured two times (Y1 and Y2) and should be analyzed by repeated measurements analysis. The effect of group on X is strong and significant (ANOVA). The effect of group on Y is also significant (repeated measurements ANOVA) but when introducing X as a covariate (repeated measurements ANCOVA), it is very small and not significant anymore. To my opinion, this probably means that group is influencing Y only indirectly.

I would like to know if the difference in p values and/or effect sizes between the group effect on Y with and without X as a covariate, is significant. Is there a way to test this?

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Yes there is an appropriate F test comparing the hierarchical models lower order model without X compared with the higher order model with X included. Alternatively you can test to see whether or not the coefficient for X is significantly different from 0. This is done with a t test. Normailty of residuals is assumed for this.

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Thank you! I am trying to find the appropriate F test in SPSS but I did not find it yet. Do you know where I should look? – Mariken Jun 5 '12 at 20:56

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