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I am working on the sample size determination for cross-over study. The aim of this study is to measure reliability of the measurements of outcome variable (continuous). For example, There will be 50 -150 clinicians in total, but probably, say, 10% will agree to participate in the study. Each clinician will get a chance to look at each patient and estimate the mortality rate two times at different time periods. (Repeated measures).

I really looking for the sample size needed to determine the reliability measures of mortality rates between the clinicians and within clinicians.

Thus I need to determine how many clinicians would be needed, and how many patients would be allocated to each clinician, and how many times?

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Do you expect that the 10% of clinicians will complete the task (2 assessments), or do you you plan some dropouts? Also, for sample size determination we generally need some information about the criterion being used (e.g., expected difference), as well as type I and II error rate. – chl♦ Nov 1 '12 at 23:36

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