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I'm a clinical researcher and I am comparing children who had fluid in the abdomen (ascites due to liver disease). I have 4 groups based on the kind of fluid analysis and in each group I have incidence of renal failure, bleed, altered sensorium, etc.

How should I compare these groups? Should I do multiple chi square tests taking 2 groups at a time? My number in each group is above 30 (but the number is different in each), and I am using SPSS 20.

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Related question: stats.stackexchange.com/questions/961/… –  nico Feb 22 '13 at 17:32

2 Answers 2

As I understand it, you have 4 treatment groups - and for each child, you have several binary outcomes? You could build a score for each patient by adding the incidence of each potentially adverse outcome. Then compare the 4 groups based on the score.

a) if your score is the result of adding up a lot of binary outcomes (say 8 or more), then do a one-way ANOVA, assuming "normality" or your score.

b) If there are fewer scores (say, 4 items), then you could do a generalized linear model with binomial response and where "treatment group" is the explanatory variable.

If you go with Peter Flom's suggestion of doing a logistic regression on each outcome, be sure to adjust the p-value. Using 5% will boost the probability of a type 1 error somewhere in your results - so take something smaller. You want $1-(1-p)^r \leq 0.05$, where $r$ is the number of outcomes and $p$ will be the significance level for each test. For 4 outcomes, you want to go with a significance level of around 1% or 2%.

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You should probably use logistic regression with each of your incidence variables as dependent variables and group as independent variable. You could do one logistic regression for each outcome.

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