SPSS Warning The large number of columns in the design matrix will cause integer overflow. The large number of columns may be due to too many levels in one or more factors, or to higher-order interactions among factors with many levels. It may also be due to too many factors This command is not executed. How do I resolve this?
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As @ttnphns suggests, you likely have misspecified your model. The only place continuous variables should be placed is under covariates. If you've double and triple checked this, then look at how many IVs (factors) you have and how many levels each IV (factor) has.
When you have a lot of IVs (or IVs with many levels) SPSS will tend to produce this error. As the error message says, there is a problem due to "due to too many levels in one or more factors, or to higher-order interactions among factors with many levels" or "It may also be due to too many factors". A google search on this error message shows a comment from David Nichols who a signature line that identifies him as "Principal Support Statistician and Manager of Statistical Support" where he implies that the design matrix is just too large.