I have serial hematological measurements data and I have plotted their means and SE in Stata. On the y-axis I have for example hemoglobin and time (visit days) on the x-axis hence I can visualize hemoglobin levels with time (whether it is decreasing or in increasing). The level decreases up to sometime and increases again. What test can use to test whether this is significant or not? Stata and R related answers are welcomed.