Stands for Generalized Estimating Equations which is an approach to estimating regression coefficients. GEE can be used on clustered / longitudinal data and has the attractive property that it provides consistent estimators of regression coefficients and unbiased inference even when the association ...

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Discrepancy between Wald test and score test in Type-3 analysis in PROC GENMOD

My logistic regression model has a binomial response and 3 categorical predictors, A, B and C. A is binary B is ternary C is ternary The observations are clustered under a factor R. There are ...
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12 views

Conditional logistic regression or GEE in PS matched study

My situation: In a cohort study, I'm trying to find the correlation between outcome & Tx (Arm A vs Arm B). However, baseline covariates are unbalance between different treatment groups. Hence, ...
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5 views

link fx and distribution in GEE model

I am working on my dissertation using a GEE approach. The reason is that my outcome is nonnormal, nonlinear, heteroscedastic, and clustered. Additionally, it is also truncated (a cutoff score) and ...
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1answer
57 views

Conditional vs. Marginal models

I have data with an outcome of 0 or 1 (binary) representing success or failure. I also have two comparison groups (Treatment vs. Control). Each subject in the study contributed 2 observations (the ...
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1answer
40 views

Interpreting a longitudinal generalized estimating equations beta cofficients

I've been struggling with wrapping my head around the GEE beta coefficients and I don't think I fully get it. There are other questions on CrossValidated that ask about GEE in the binary context ...
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16 views

SPSS Generalized Estimating Equations (GEE) with 2 nested subject variables?

I have an intercept-only model with 1 dependent variable and 2 subject variables (participants and participant groups). Technically, the participants variable should be nested within the participant ...
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28 views

Model selection of GEE using QIC: plausible models

I'm using GEE (generalized estimating equations) for the first time and selecting between multiple GEE using difference in QIC. The models differ in their independent variables. Here's my questions: ...
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16 views

Best method to analyse longitudinal recurrent count data

I want to analyze count data, more specifically number of prescriptions over 10 years. My first idea was to use the GEE Poisson. However, after reading some papers about recurrent history analysis I ...
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16 views

Why does GEE produce the same parameter estimates as OLS?

The quasi-likelihood function optimized under GEE is: $S_k(\beta)=\sum_{i=1}^{K}\frac{\partial\mu_i}{\partial\beta_k}\nu_i^{-1}(y_i-\mu_i)=0,$ where $\mu_i=h(\textbf{x}_i,\beta)$ is the conditional ...
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85 views

Case-control Matched Clustering in Generalized Estimation Equation (GEE) (R:geeglm)

Question: I have matched case-control data and I would like to take advantage of that in my GEE analysis. In the standard approach to GEE analysis, we call each subject a cluster and fit ...
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1answer
29 views

Analyzing binomial distributed variables

I have the following situation. A subject comes to the clinic at day 1 and is evaluated using a 10 item checklist. The sum of those 10 items is the subjects score. A intervention is performed. The ...
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1answer
26 views

Repeated measurements, multiply assessed exposure with single outcome

We have data points from a prospective study in which participants were assessed 3 times during follow-up for an exposure of interest, and during a 4th follow-up they were assessed for an outcome of ...
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22 views

GEE model returns GLM results

I have simulated some longitudinal data with 100 subjects and 7 measurements per subject. My data has random intercept which will induce "exchangeable" correlation matrix. My goal is to fit two ...
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16 views

GEE with three measurement points

I have done some research about predicting the occurrence of a disease. I had 3 measurements during 6 month and conducted a GEE with the dichotomous dependent variable Disease (yes/no) and several ...
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1answer
47 views

Calculating AUC for a GEE

I have used the geeglm package to build a GEE that predicts animal activity (a binary response, active or not) from weather data (e.g., Temperature, a continuous variable). TEMPC <- ...
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1answer
64 views

AR(1) working correlation matrix with GEE

I'm attempting to fit a GEE model and I have a question about using the AR(1) working correlation matrix. I've read some conflicting information about this correlation matrix. In some books and ...
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6 views

General question about generating data, using GEE and testing the results

I am new to GEE and try to understand it by using it. Now I have troubles to understand how the "gee" package in R works. I start by explaining what I intended to generate and what my questions are. ...
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10 views

Investigation of X on time 1 has an influence on the change of Y between time 1 and time 2

I would like to investigate if X on time 1 has an influence on the change of Y (= absenteeism) between time 1 and time 2: does X on time 1 increases or decreases Y on time 2 controlled for Y on time ...
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39 views

How does GEE (Generalized Estimating Equation) treat different cluster size?

I have a population of 200, 000+ patients and their hospital visit information. I'm trying to see if having a certain disease would have an effect on whether they will have readmission or not (this is ...
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26 views

GEE Logistic Model with Subject Specific Predictions?

I have fit a marginal logistic model or GEE Logistic Regression model using SAS' proc genmod to obtain estimated parameters associated with mortality (death). Using SAS, I am able to obtain ...
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14 views

GEE model with more x time points than y?

I have a dataset that measures a bunch of variables on mothers starting before the baby is born (two time points), and continues to measure them once the baby is born (3 time points). Once the baby is ...
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1answer
121 views

What does id (cluster) mean in gee?

I wanted to use poisson glm model which would take serial correlation (AR-1) and overdispersion into account. I was directed to use gee, but ...
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34 views

Using QIC in glm (geeglm) when there is a warning of glm.fit: fitted probabilities numerically 0 or 1 occurred

I am using geepack in R to look for the best model for my data. I run the gee function with family=binomial(link="logit"). From the results I use QIC to find the ...
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28 views

Use clustered S.E. or FE/RE for binary data in an experimental within-subject design?

I am analyzing a 2x2 experimental within-subjects-design, i.e. I have data from all subjects for all four possible treatment combinations. Lets say treatment X has states X1 and X2 and treatment Y ...
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21 views

longitudinal data with changing skew over time

I want to examine a group by time interaction in a pre-post treatment study. Initially, symptoms are high so the skew is positive. But at the end of treatment the symptoms are low, so the distribution ...
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43 views

Large samples and the p-values almost zero in GEE models

I’m trying to find correlations between some environmental variables and a binary variable, berried/not berried females (rock lobster). I have 20 years of data that were sampled on a daily basis, ...
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1answer
86 views

General estimating equation with zero-inflated continuous data in R

I'm running a General Estimating Equation using the geepack package in R. I'm wondering what distribution family would be appropriate for my data, which are zero-inflated and continuous. I would have ...
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32 views

What is the appropriate link fucntion in GEE for longitudinal data where distribution changes in time?

I'm modeling treatment outcome data in a GEE with Group, Time, and their interaction. At baseline everyone is highly symptomatic, thus the distribution is negatively skewed. At follow up most people ...
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41 views

Generalized Estimating Equations with independance correlations structure versus quasi-approach versus negative binomial glm

I would like to know when it is appropriate to use a GEE with an independence working correlation structure, particularly in regard to a data set I am analysing. I have data on pollinator visits, ...
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46 views

Specifying distribution in generalized estimating equation GEE

GEE allows you to identify the distribution of the outcome variable and appropriate link function. How do you make this selection in a longitudinal model where the distribution changes in time. An ...
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34 views

Modeling change over time when response variable has different range and variance?

Some background: I am working with data from a large cohort study. My outcome is a measure of fine motor skills, and was adapted from a psychometrically validated instrument (the short version ...
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44 views

How to analyze nested, repeated and unbalanced questionnaires where the outcome is binary?

Background: My data was collected once a year for 6 years using the same questionnaire. All responses have a person-specific ID. 18 554 responses from 5 654 unique persons were collected from 7 ...
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69 views

Score test or tests based on empirical standard error estimates in Logistic Marginal Model?

I am trying to figure out whether to use a score test the other test (I think it's a test based on empirical standard error estimates?) when looking for the effect of a continuous variable in a ...
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49 views

How are complex sample analysis and GEE different from each other?

I am currently analyzing a national survey data. The survey design is complex: 1) strata 2) cluster 3) 2-stage, 4) sampling weight. There are strata; PSUs(agencies) were selected randomly and ...
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42 views

Generalized Estimating Equations- How many predictor variables are too many based on sample size?

I am conducting analyses on wild animals, on how diet of an individual changes based on environmental changes. I will list the setup of my dataset below. Until now, I have been running independent ...
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1answer
66 views

GEE/Mixed model can i use time as a factor variable?

I have data on a compound measured on 1) 0 min, 2) 10min, 3) 60min, 4) 1day and 5) 2months. i have coded these time points as 1,2,3,4 and 5, the compound has a cubic function in time when modeled on ...
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34 views

geeglm not recognizing clusters

I am fitting a geeglm model and it is not recognizing the clustering. my model is ...
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89 views

GEE as alternative for Linear Mixed Models

A linear mixed model requires the residuals to be normal. In the case of a simple linear mixed model with a random intercept only, a colleague of mine was arguiing that I could just use a GEE with an ...
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65 views

Graphing GEE Models in R?

I am currently working on a biological dataset where I am attempting to fit a detection function (Detection probability as a function of distance). I have been using the package geepack (in R-studio) ...
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1answer
42 views

covariance matrix of residuals from a fitted model to decorrelate residuals

I fit a geeglm model with clustered data and now I would like to decorrelate the residuals of the model in order to run model diagnostics. I read that if I can obtain the covariance matrix of the ...
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61 views

geeglm Model matrix is rank deficient after scaling the predictors?

Trying to run a linear regression with repeated measure using geeglm. Here is my original model: ...
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111 views

What to use when chi-square independence assumption is violated

I'm trying to describe the characteristics of the sexual partners of each participant. There are multiple partners per participant. All of the variables in my analysis are categorical, so originally I ...
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111 views

GEE and post hoc comparisons

I am trying to analyze a dataset using the GEE. This is what I have so far ...
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119 views

GEE with exchangeable working covariance vs. GLM and using Clustered Robust standard errors?

I'm analysing a dataset including 100 individuals. These 100 individuals provided self-reported depression sores on equally spaced 4 occasions (every three months). The main independent outcome is ...
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1answer
151 views

Can someone look at my method for fitting a GEE to my data?

I’ve been doing some statistical analyses in R on some data. It’s for use in a manuscript I’m hoping to get published in a biological journal. Unfortunately, the tests I ended up having to run are ...
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50 views

Contradictory results in GEE with or without a covariate

Three independent variables, one is between-group with 2 levels, the other two are within-group with 2 and 4 levels respectively. Another continuous variable (IQ) is controlled as a covariate. The ...
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83 views

GEE model for repeated skewed outcome and group mean centered time varying covariates

I have used GEE approach (log link with gamma distribution) to explore factors that are associated with outcomes of interest. My primary outcome of interest is highly skewed costs associated with an ...
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133 views

geepack: parameter estimates change sign depending on correlation structure

I'm working on a dataset with the following variables: ...
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37 views

GEE Repeated Measurements: Specifying Measurement ID

Say I have 10 subjects, coming from three groups. In each subject I make two measurements (one on the left, one on the right). ...
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86 views

How to analyze this messy design?

I need to analyze a data-set, with a very messy design, I am not sure how. I will try to make it simple. A new kind of stitches was invented, and is tested vs. 2 old kind of stitches. I will call ...