# Tagged Questions

Meta-analysis refers to methods focused on contrasting and combining results from different studies, in the hope of identifying patterns among study results, sources of disagreement among those results, or other interesting relationships that may come to light in the context of multiple studies.

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### Statistics for multi-test replicated correlation analysis

I'm analyzing pairwise correlations of time series between two different types of microarrays done for several samples as biological replicates. So, I have M1 number of variables on type 1 array, M2 ...
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### How to perform meta-analysis comparing different proportional mortality ratios of subgroups?

I am working on a meta-analysis of observational studies (basically 39 retrospective papers on different surgical interventions for one condition). I've obtained different weighted proportions ...
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### How can I combine data from 2 separate experiments?

I am a scientist and by no means a statistician. I have, I think, a very basic question for you all. I have performed the same experiment twice (analyzing levels of a certain protein) and am ...
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Suppose we want to make inference on an unobserved realization $x$ of a random variable $\tilde x$, which is normally distributed with mean $\mu_x$ and variance $\sigma^2_x$. Suppose there is another ...
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### Meta Analysis: Pooling samples or determine an average effect size

I am new to meta analysis and how I understood the terminology is that there are actually two ways of performing a meta analysis. Let's consider 5 clinical studies with fixed effects. Fixed effects in ...
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### What is the difference between a frequentist approach with meta-analysis and a Bayesian approach?

Say I am performing an analysis looking at a particular health measure. I am interested in the difference in that measure between patients and controls and wether or not the difference is different ...
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### How to use a meta-analysis to assess the equivalence of two different procedures?

I'm making a comparison of two surgical procedures, and I want to know how I can analyze the data I have for a meta-analysis. The overall surgical procedure is the same, but some authors choose to ...
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### Meta-analysis with zero values for mean and sd

I want to do a meta-analysis with count data for treatement/control cases (abundance of sea polichaetos). My problem is that I need to use zero values (an informative zero value) for the mean and ...
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### New method for meta-analysis to determine agreement between multiple sources

I'm writing a paper on a method to determine the statistical significance of whether a sample of sources are in mutual agreement on specific premises. This is done by counting the number of sources in ...
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I am trying to determine exactly what method PLINK uses for meta-analysis. I can't find it in the program documentation/FAQ anywhere. Inverse variance? (given the meta command only requires effect ...
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### Multilevel Meta-analysis with several treatments

I have data on a number of studies comparing response rates to various treatments of a disorder. There are six different treatments, and some studies only test a single treatment. For each treatment ...
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### Estimating absolute difference between two conditions

A clinical trial examines the effect of two treatments upon lung function. Patients in each group contribute data at baseline and at the end of the trial. Baseline data are provided for each group ...
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### Analysing Several Existing Data Sets

I have several data sets that gathered similar data on a similar population group in one setting. Can I simply combine the data on common variables or do I need to engage in some pooled analysis?
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### Can probability be used to calculate (any?) effect size measurement? Version 2

A similar question has been answered, but I reframed here to remove the ambiguity in that question as to what I'm after... (as a survival analysis was not performed) For example, some studies report ...
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### Is there a sensible way to calculate effect size from data reported in percentages?

Is there a sensible way to calculate effect size (ideally Hedges g* / Cohen's d or log response ratio) from data reported in percentages? An example of such data below. I would, for instance, be ...
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### Meta analysis: comparing effects of two risk factors

I am conducting a systematic review to compare the effect of intervention A vs. B on outcome Y (A, B, Y binary variables). So far the collected studies are categorized as below: 7 studies on both ...
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### How can I calculate the hazard ratio (HR) from one-sided $p$ values on stratified log-rank?

Recently, I have been preparing to perform a meta-analysis about the treatment of pancreatic cancer. When I extracted time to event (survival-type) data from the publications, I encountered some ...
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### How to calculate the first principal component from multi-data sets (using WGCNA)

I have a bunch of datasets (gene expression profiles). From the datasets, I am gonna analyze co-expression profiles using WGCNA ...
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### Meta analysis of summary data or model of raw data?

I have data of the following form: Sample MeasureZZ Time Event S1 M1 t1 e1 .... I have calculated the influence of ZZ on survival by ...
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### Adjust estimate precision by sample size

I wish to find comparable SDs/Confidence Intervals for two parameters. One parameter has been measured by only one (new) study that reports the standard error. Here, t value, sample size and SD are ...
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### Overall estimate, obtained in a mixed model, does not look like subsets average

I'm doing a meta-analysis, based on literature data. My goal is to compare OR of a specific event occurrence in men and women. Analysis was done by fitting the mixed effect regression model (with R ...
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### How many chains should we choose in multi-treatment meta-analysis using MCMC and WinBugs

I am learning to undertake multiple treatment comparison meta-analysis (aka network meta-analysis or MTM) using WinBugs. One of the specifications are choosing the number of chains to run in the MCMC ...
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### How to do meta-analysis and create forest plots using Beta correlation coefficients

Does anyone knows how to do meta-analysis and create forest plots using beta-correlation coefficients?
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### Publication bias in meta-analysis of single case studies

Is there a way of investigating publications bias in a meta-analysis of single case studies? Usually one can assess publication bias using funnel plots or Egger's test to assess funnel plot asymmetry. ...