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Remember that all models are wrong; the practical question is how wrong do they have to be to not be useful 
--   George Box & Norman R. Draper, Empirical Model-Building and Response Surfaces

Far better an approximate answer to the right question, which is often vague, than an exact answer to the wrong question, which can always be made precise.
  --   John Tukey, The future of data analysis. Ann. Math. Stat. 33 (1), (1962)

It is no more appropriate to tailor a course to the desires of the student than it is to modify the driving test according to the wishes of learner drivers.
  --   Stephen Senn, On thinking and learning. RSS News
, December 2007

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