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How I can compare two Likelihood-ratio test and hazard functionsfunction in survival analysis?

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Suppose that the data below are remission times (in weeks) of two treatment groups and that data follow an exponential distribution.

Group 1: (6,6,7,8,10,13,16,22,23,6+,9+,10+,11+,17+,19+,20+,25+,32+,32+,34+,35+)

Group 2: (1,1,2,2,3,4,4,5,5,7,8,8,9,11,11,12,12,15,17,22,23)

where $+$ mean censored data.

How I can use the likelihood ratio test in this case to test the hypothesis that the remission risk in Group 2 is 5 times the risk of Group 1?

Let $T\sim \exp(\alpha)$ then $$f(t)=\alpha\exp(-\alpha t)\qquad t>0$$

$$S(t)=P(T\geq t)=1-F_T(t)=\exp(-\alpha t)$$

then

$$\lambda(t)=\frac{f(t)}{S(t)}=\frac{\alpha\exp(-\alpha t)}{\exp(-\alpha t)}=\alpha$$

So I think if the $\lambda_1(t)=\alpha_1$ and $\lambda_2(t)=\alpha_2$ then the hypothesis is $$H_0:\lambda_2(t)=5\lambda_1(t)$$ in the particular case of exponential $$H_0:\alpha_2=5\alpha_1$$

What I think to do is find the likelihood estimate for two groups and compare

For Group 1

$$\alpha_1=\frac{\sum \delta_i}{\sum t_i}$$

where $\delta=1$ if are not censoring and $\delta=0$ if a particular time is censoring, and $t_i$ are the remission times.

But in this case in the Group 2 I have no censored data, then the likelihood estimate is different.

I'm a litle lost. How the right way to test it?

This question is from an old exam, and need to be done at hand. I don't understand how I can use the likelihood test in this case, because if two groups follow a exponential distribution, the degrees of freedom in the likelihood test will be 0, what no make sense.

Suppose that the data below are remission times (in weeks) of two treatment groups and that data follow an exponential distribution.

Group 1: (6,6,7,8,10,13,16,22,23,6+,9+,10+,11+,17+,19+,20+,25+,32+,32+,34+,35+)

Group 2: (1,1,2,2,3,4,4,5,5,7,8,8,9,11,11,12,12,15,17,22,23)

where $+$ mean censored data.

How I can use the likelihood ratio test in this case to test the hypothesis that the remission risk in Group 2 is 5 times the risk of Group 1?

Let $T\sim \exp(\alpha)$ then $$f(t)=\alpha\exp(-\alpha t)\qquad t>0$$

$$S(t)=P(T\geq t)=1-F_T(t)=\exp(-\alpha t)$$

then

$$\lambda(t)=\frac{f(t)}{S(t)}=\frac{\alpha\exp(-\alpha t)}{\exp(-\alpha t)}=\alpha$$

So I think if the $\lambda_1(t)=\alpha_1$ and $\lambda_2(t)=\alpha_2$ then the hypothesis is $$H_0:\lambda_2(t)=5\lambda_1(t)$$ in the particular case of exponential $$H_0:\alpha_2=5\alpha_1$$

What I think to do is find the likelihood estimate for two groups and compare

For Group 1

$$\alpha_1=\frac{\sum \delta_i}{\sum t_i}$$

where $\delta=1$ if are not censoring and $\delta=0$ if a particular time is censoring, and $t_i$ are the remission times.

But in this case in the Group 2 I have no censored data, then the likelihood estimate is different.

I'm a litle lost. How the right way to test it?

Suppose that the data below are remission times (in weeks) of two treatment groups and that data follow an exponential distribution.

Group 1: (6,6,7,8,10,13,16,22,23,6+,9+,10+,11+,17+,19+,20+,25+,32+,32+,34+,35+)

Group 2: (1,1,2,2,3,4,4,5,5,7,8,8,9,11,11,12,12,15,17,22,23)

where $+$ mean censored data.

How I can use the likelihood ratio test in this case to test the hypothesis that the remission risk in Group 2 is 5 times the risk of Group 1?

Let $T\sim \exp(\alpha)$ then $$f(t)=\alpha\exp(-\alpha t)\qquad t>0$$

$$S(t)=P(T\geq t)=1-F_T(t)=\exp(-\alpha t)$$

then

$$\lambda(t)=\frac{f(t)}{S(t)}=\frac{\alpha\exp(-\alpha t)}{\exp(-\alpha t)}=\alpha$$

So I think if the $\lambda_1(t)=\alpha_1$ and $\lambda_2(t)=\alpha_2$ then the hypothesis is $$H_0:\lambda_2(t)=5\lambda_1(t)$$ in the particular case of exponential $$H_0:\alpha_2=5\alpha_1$$

What I think to do is find the likelihood estimate for two groups and compare

For Group 1

$$\alpha_1=\frac{\sum \delta_i}{\sum t_i}$$

where $\delta=1$ if are not censoring and $\delta=0$ if a particular time is censoring, and $t_i$ are the remission times.

I'm a litle lost. How the right way to test it?

This question is from an old exam, and need to be done at hand. I don't understand how I can use the likelihood test in this case, because if two groups follow a exponential distribution, the degrees of freedom in the likelihood test will be 0, what no make sense.

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user72621
user72621

How I can compare two hazard functions in survival analysis?

Suppose that the data below are remission times (in weeks) of two treatment groups and that data follow an exponential distribution.

Group 1: (6,6,7,8,10,13,16,22,23,6+,9+,10+,11+,17+,19+,20+,25+,32+,32+,34+,35+)

Group 2: (1,1,2,2,3,4,4,5,5,7,8,8,9,11,11,12,12,15,17,22,23)

where $+$ mean censored data.

How I can use the likelihood ratio test in this case to test the hypothesis that the remission risk in Group 2 is 5 times the risk of Group 1?

Let $T\sim \exp(\alpha)$ then $$f(t)=\alpha\exp(-\alpha t)\qquad t>0$$

$$S(t)=P(T\geq t)=1-F_T(t)=\exp(-\alpha t)$$

then

$$\lambda(t)=\frac{f(t)}{S(t)}=\frac{\alpha\exp(-\alpha t)}{\exp(-\alpha t)}=\alpha$$

So I think if the $\lambda_1(t)=\alpha_1$ and $\lambda_2(t)=\alpha_2$ then the hypothesis is $$H_0:\lambda_2(t)=5\lambda_1(t)$$ in the particular case of exponential $$H_0:\alpha_2=5\alpha_1$$

What I think to do is find the likelihood estimate for two groups and compare

For Group 1

$$\alpha_1=\frac{\sum \delta_i}{\sum t_i}$$

where $\delta=1$ if are not censoring and $\delta=0$ if a particular time is censoring, and $t_i$ are the remission times.

But in this case in the Group 2 I have no censored data, then the likelihood estimate is different.

I'm a litle lost. How the right way to test it?