As I don't have enough reputation to comment, I'd put it here as an 'answer'.
But first of all, I am not very sure what you're looking for. I'd try my best to guess what you mean and please correct me if I'm wrong.
You have two difference statistical models, and the two models were based on two difference data-sets. You want to compare them for statistical significance.
Short answer: no, you can't.
Long answer: Basically when you compare two models, you want to know which one have a greater explanatory / predictive power with reference to the same data-set. Although you can compare the AICs (asymptotically equal to cross-validation errors) or even the R^2 (for linear regressions) but it is almost impossible to interpret the comparison. IN addition, to my knowledge, most common statistical tests for model fitness are designed for nested models only, i.e. your model A is a subset of model B.