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Can anyone recommend a paper which provides a nice introduction or summary of group sequential design.

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Personally- I find Group Sequential and Adaptive Designs - A Review of Basic Concepts and Points of Discussion by Marc Vandemeulebroecke a great reference.

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  • $\begingroup$ Does this article provide a discussion on frequentist vs. bayesian approach to RCTs? $\endgroup$
    – chl
    Commented Jan 20, 2013 at 9:23
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    $\begingroup$ @chl: No. Frequentist only. $\endgroup$
    – JohnRos
    Commented Jan 20, 2013 at 12:30
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Pocock "Group Sequential Methods in Clinical Trials" 1977 Biometrika is a foundational article and well worth the read.

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regulatory guidelines often provide a very useful and succinct introduction; they distill much of the thinking that originally appears in esoteric stats journals, and reduce it to the salient info. For example, see the FDA Guidance for Industry document on adaptive designs, section V part D re sequential methods.

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