Let's take, as a simple example, the two-tailed one-sample hypothesis test on the population mean. Suppose we've determined an $\alpha$-level a priori.
Let $X_1, \dots, X_n \overset{\text{iid}}{\sim}\mathcal{N}(\mu, \sigma^2)$. In this setting, given a value $\mu_0$, we have the null and alternative hypotheses $H_0: \mu = \mu_0$ and $H_1: \mu \neq \mu_0$.
Let $\bar{X}_n$ be the sample mean of $X_1, \dots, X_n$ and $S^2$ be the unbiased estimator of $\sigma^2$, with $\bar{x}_n$ and $s^2$ being the observed values.
We know that $$\dfrac{\bar{X}_n - \mu}{\sqrt{S^2/n}} \sim t_{n-1}$$ i.e., a $t$-distribution with $n-1$ degrees of freedom. Under $H_0$, we have that $$\dfrac{\bar{X}_n - \mu_0}{\sqrt{S^2/n}} \sim t_{n-1}\text{.}$$ Then we compute a $p$-value $$p = \mathbb{P}\left(|T| \geq \dfrac{\bar{x}_n - \mu_0}{\sqrt{s^2/n}} \right)$$ where $T \sim t_{n-1}$ and if $p < \alpha$, we reject $H_0$ and state there is evidence for $H_1$.
Now, I've done this procedure for years, and I'm a bit embarrassed to ask this, given that I hold a MS degree: but exactly why does having $p < \alpha$ indicate incompatibility with $H_0$ and evidence for $H_1$? Mathematically, all it is at the end of the day is the probability that your random variable $T$ takes on a value at least as extreme (in absolute value) than the one yielded by the sample. But I fail to see why having $p < \alpha$ indicates that we have evidence to reject $H_0$.
Perhaps this may have been covered in Casella and Berger and I've forgotten the details.