Context is king. If "the king is dead" was writting on a wall does it mean something different than if it is written on the front page of every newspaper on earth?
If you are making a process-production experiment then both time and budget are highly constrained, but you are trying to make a smaller incremental change to find the general direction of improvement.
If you are working with an amazingly complex phenomena, like in a research lab then you need very elaborate, iterated, re-optimized experiments but time is less of an issue. Detailed and effective results are everything. It is a different climate - a different context.
In general the fundamentals are the same, but the budget, level of detail, and time-constraints define the differences in the approach.