The spirit of this question comes from "Ordinary Monte Carlo", also known as "good old-fashioned Monte Carlo"
Suppose I have a random variable $X$, with
$$\mu := E[X]\\
\sigma^2:=Var[X]
$$
Both are unknown values, because the probability distribution function of $X$ is unknown (or the computations are intractable).
Either way, suppose we can somehow simulate $n$ draws $X_1,X_2,\dots,X_n$ (these are independent and identically distributed) from the distribution of $X$. Let us define the sample parameters
$$ \hat{\mu}_n := \frac{1}{n}\sum_{i=1}^{n}X_i\\ \hat{\sigma}_n^2 : = \frac{1}{n}\sum_{i=1}^{n}(X_i-\hat{\mu}_n)^2 $$
According to the Central Limit Theorem, as $n$ becomes very large, the sample mean $\hat{\mu}_n$ will closely obey a normal distribution
$$ \hat{\mu} \sim N(\mu,\frac{\sigma^2}{n}) $$
Before we can calculate confidence intervals, the author states that since we do not know $\sigma^2$, we will make the estimation that $\sigma^2 \approx \hat{\sigma}^2$, or more precisely for an unbiased estimate $\sigma^2 \approx \frac{n}{n-1}\hat{\sigma}^2$, and we can proceed from there using standard techniques.
Now, while the author mentions the importance of $n$ sufficiently large (number of draws per simulation), there is no mention about the number of simulations and its effect on our confidence.
Is there any advantage of running $k$ simulations (performing $n$ draws each time) to obtain several sample means $\hat{\mu}_{n,1}, \hat{\mu}_{n,2}, \dots \hat{\mu}_{n,k}$, and then use the means of the means to improve our estimates and confidence regarding the unknown $\mu,\sigma$ of $X$?
Or does it suffice to just draw $n$ samples from $X$ in a single simulation, as long as $n$ is sufficiently large?