How to extract data from published articles (RCTs) to do a meta-analysis? I am doing a meta analysis for the first time and have a few basic questions regarding statistical analysis. 
Let's say I have one study where the primary outcome (thrombosis) in the 2 treatment groups (intervention v. placebo) was compared using the Mantel-Haenszel chi-square test.  It does not report df in the article (is this something I can deduce?). Then it tells me that "Treatment effects were expressed as a weighted average of the strata-specific relative risks." Is this something I need to consider for the meta-analysis statistical calculation? If so, what does it mean?
In the results we learn "Among the 866 participants who had patency assessed, the primary outcome of fistula thrombosis at 6 weeks occurred in 53 participants (12.2%) in the clopidogrel group compared with 84 participants (19.5%) in the placebo group (relative risk, 0.63; 95% CI, 0.46-0.97;P=.018).
What do I do with all this information? I tried using a computerized program, but I didn't know what to fill all the blanks in with...
In the second study, we have the following:
"The hazard ratio was 0.81 (95% CI, 0.47 to 1.40) in favor of aspirin and clopidogrel therapy, but the reduction was not significant (P= 0.45). Although the event rates in the two treatment arms converged, there was no evidence that the proportional-hazards assumption was violated (P 0.53). The annual hazard rate for thrombosis among  articipants receiving placebos was 0.59 (95% CI, 0.39 to 0.87), compared with 0.47 (95% CI, 0.31 to 0.71) among participants receiving aspirin and clopidogrel. The absolute
risk reduction for the group receiving aspirin and clopidogrel was 0.03 (95% CI,-0.19 to 0.07), and the number needed to treat was 33.3 (95% CI, 14.9 to >/=1000)."
Regarding analysis, it states: "The cumulative incidence of the first episode of thrombosis was estimated with the Kaplan-Meier method, and differences in rates between treatment groups were tested with the log rank test. The cumulative incidence of the first bleeding event was analyzed in a similar manner."
What do I do with all this information? Thank you for any help you can provide.
 A: Your question indicates, to me, you're not yet ready to embark on the data abstraction portion of your meta-analysis. Your question needs refining, and you need to decide exactly what you're interested in asking. In your examples above, you appear to be interested in the main reported effects of the RCTs, which are found in the following places:
"Among the 866 participants who had patency assessed, the primary outcome of fistula thrombosis at 6 weeks occurred in 53 participants (12.2%) in the clopidogrel group compared with 84 participants (19.5%) in the placebo group (relative risk, 0.63; 95% CI, 0.46-0.97;P=.018)."
and 
"The hazard ratio was 0.81 (95% CI, 0.47 to 1.40) in favor of aspirin and clopidogrel therapy".
All the other information is set dressing for specific study-related information, and you can probably discard it unless you think it matters to your question. Generally however, data can be abstracted into a simple Excel spreadsheet, for later analysis in the statistics package of your choice. I'd include the following fields:


*

*Study Authors

*Publication Year

*Sample Size

*Some coding for type of study (Case-Control, RCT, Cohort) - you can ignore this if you are really just extracting RCTs

*ln(Effect Estimate). So in the case of the examples above, ln (0.63) and ln(0.81) if you are looking into the main effect of treatment.

*Standard error of the estimates, which you can back calculate from the confidence interval.

*What kind of estimate was this? (RR vs. HR in your case)

*Multiple columns of any study covariates that interest you. What setting, country, etc. the studies were in, were they prospective or retrospective, etc.

