The t-statistic makes a lot of sense as a test statistic; many people find it intuitive. If I quote a t-statistic of 0.5 or 5.5, it tells you something - how many standard errors apart the means are.
The difficulty - at least with moderate non-normality - is not so much with using the statistic as using the t-distribution for its distribution under the null. The statistic is quite sensible.
Of course, if you expect substantially heavier tails than the normal, a more robust statistic would do better, but the t-statistic is not highly sensitive to mild deviations from normality (for example it's less senstive than the variance-ratio statistic).
If you want to use just the numerator of the statistic, that's great, it makes perfect sense as a permutation statistic, if you're interested in a difference in means. If you're interested in a more general sense of location shift, it opens up a plethora of other possibilities.
You're right to think there's a lot of freedom to chose a statistic and to tailor it to the particular circumstances - what alternatives you want power against, or what possible problems you'd like to be robust to (contamination, for example, can impact power).
There are really almost no restrictions - you're free to choose almost anything, including useless test statistics. There are some considerations that you really should think about when choosing tests, of course, but you're free not to.
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That said, there are some criteria that can be applied in various circumstances.
For example, if you're particularly interested in a specific kind of hypothesis, you can make use of a statistic that reflects it - for example, if you want to test a difference in population means, it often makes sense to make your test statistic related to a difference in sample means.
If you know something about the kind of distribution you might have - heavy tails, or skew, or notionally light tailed but with some degree of contamination, or bimodal, ... you can devise a test statistic that might do well in such circumstances, for example, choosing a statistic that should perform well in the anticipated situation but has some robustness to contamination.
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Simulation is one way to investigate power under various situations.