it would be better to explain this in matrix notation. Suppose the general Gauss-Markov linear model $$\mathbf{y = X \boldsymbol \beta + \boldsymbol \epsilon}$$For your case, $\mathbf{X}$ = ($\mathbf{1}$, $\mathbf{x_1}$, $\mathbf{x_2}$) and $\mathbf{\boldsymbol \beta} = (\alpha, \; \beta_1 \; \beta_2)'.$
The OLS estimator is $$\hat{\boldsymbol \beta} = \left(\mathbf{X}'\mathbf{X} \right)^{-1}\mathbf{X}'\mathbf{y}.$$ Since $\mathbf{y} \ \sim \ N(\mathbf{X \boldsymbol \beta}, \sigma^2)$, then $$\hat{\boldsymbol \beta} \ \sim \ N \left(\mathbf{X \boldsymbol \beta}, \sigma^2(\mathbf{X}'\mathbf{X})^{-1} \right).$$
Based on the above result, you are able to derive the distribution of $Z = \alpha_1 \beta_1 + \alpha_2 \beta_2$ if you write $Z = \boldsymbol \lambda' \boldsymbol \beta$, where $\lambda' = (0, \alpha_1, \alpha_2)$. Denote correspondingly that $$\hat{Z} = \alpha_1 \hat{\beta}_1 + \alpha_2 \hat{\beta}_2 = \boldsymbol \lambda' \hat{\boldsymbol \beta},$$
then you can easily get that $$\frac{\hat{Z} - Z}{\sigma\sqrt{\boldsymbol \lambda' (\mathbf{X}' \mathbf{X})^{-1} \boldsymbol \lambda}} \ \sim \ N(0, 1).$$
Note that $\sigma$ is unknown, so you cannot construct the confidence interval based on the normal distribution. A rigorous approach is to derive the confidence interval based on a $t$-test statistic (I just ignore the derivation but give the result, you should be able to find details in any linear model book or through website). Specifically,$$\frac{\hat{Z} - Z}{\hat{\sigma} \sqrt{\boldsymbol \lambda' (\mathbf{X}' \mathbf{X})^{-1} \boldsymbol \lambda}} \ \sim \ t(n-p),$$
where $\hat{\sigma}^2 = \frac{\mathbf{y}'(\mathbf{I - P_X}) \mathbf{y}}{n-p}$, $\mathbf{P_X}$ is the projection matrix, and $p = rank(\mathbf{X})$.