I want to conduct a Chi square test of independence.
I have three different genotypes (CC/CG/GG, independent variable) and "health conditions" (outcomes) which is basically a patient group with a certain disease and a control group without the disease.
Does it sound right if my null hypothesis states that "the distribution of these alleles in these "study groups" doesn't influence disease outcome"
Whereas the alternative hypothesis says that "the distribution of these alleles in these study groups does influence disease outcome".
Is i formulated in a right way? Because I can't state (with the Chi square) that there are a certain risk-allele that lies behind disease.
And lastly, I have heard that you can only use odds ratio if it is a 2x2 table, but if I use a "dominant" model of Pearsons Chi-square then the result would no longer be significant and there should no longer be any point to perform a OR.
Thankful for comments!