# Is Fisher's exact test appropriate if one cell is much larger than the rest?

Say I have 2 * 2 contingency table where one of the cells is substantially larger than all the other cells, like this:

   P1  P2
C1 6   11
C2 81  12201


Is it appropriate to use Fisher's exact test here and can you point me to a reference defending that choice? If not, what would be a better test for significance?