I need to test data on patients in a pre/post setting. I have data on the counts of seizures in a starting interval, and then another count of seizures after the patient was treated for the same time interval.
I'd like to test the reduction (if it exists) offered by the treatment. I have no other adjustment variables and am not sensitive to the timing of the data (time doesn't matter its just paired differences).
Data looks something like:
ID PreMedSeizures OnMedSeizures 1 20 10 2 150 60 3 30 40 4 200 120 5 1000 500 ...
My initial thought was a simple test of location (t-test, Wilcox, whatever) dealing with all of the non-normalities, perhaps trimming outliers (most of the data looks like lines 1-3, there are a few that resemble 5) but on second blush this seems insufficient. Raw numbers of seizures does not capture the magnitude of improvement--or worsening--for each patient. For example, ID 1 had a 50% improvement, and ID 5 did as well..but if you test for location you're looking at raw numbers of seizures and that magnitude gets buried.
So, I went the real complicated route and thought about poisson and hierarchical models but I'm concerned this is way over-complicating the problem. There should be something simpler.
Perhaps the simple answer is to work with the proportions (Om/Pm), but I'm not sure what test that would be either. Seems heretical. Maybe I just need to transform the paired-differences before testing? I need some help. Thanks.