I have a dataset of cases and age & sex matched controls (n=25). I need to do a statistical test to find the significantly different incidences of ICD-9 codes using a p-value or similar measure.
What test should I use in this scenario and how should I define significance ? Given the low number of samples, should I use a p-value higher than 0.05 ? R script/pro-tips to deal with small data sets are appreciated .
This is my tab-delimited data file looks like.
ICD-Code Description Cases Controls p-value 401.1 Hypertension, benign 14 3 ? 405 Secondary hypertension 20 1 ? 250 Diabetes mellitus 20 20 ? . . .
EDIT: I am trying to understand the trade-offs in selecting an appropriate p-value to define the significance with my dtaand a suitable multiple comparison method here. Any suggestions on such aspects ?