We are writing a protocol for PROSPERO for a pairwise meta-analysis comparing comparing two cardiovascular treatments in terms of their effects on a dichotomous endpoint, such as death. We expect to include 5 o 6 homogeneous trials, eventually (thus most likely statistical inconsistency will be minimal, e.g. I-squared will be 0).
We are uncertain as to whether opt for the Peto method to compute odds ratios, or the Mantel-Haenszel fixed-effect method.
It appears the Peto method might be less robust, as it relies on more assumptions (eg Khera et al), but the Cochrane Collaboration considers both Peto and Mantel-Haenszel approaches as fine (see for instance section 9.4.4 Meta-analysis of dichotomous outcomes of the Cochrane Handbook for Systematic Reviews of Interventions).
Any suggestion of which method to prefer for the primary analysis in the protocol (leaving the other one for sensitivity analysis)?