Experiment: Given mice of two genetic backgrounds (normal, mutant), is there a difference in brain inflammation as determined by fluorescence intensity of an inflammatory marker?
Data: 19 mice (12 in genotype = normal, 7 in genotype = mutant) across 90 observations (3-7 observations per mouse) were analyzed.
Model (code in R):
model = lme(inflammation ~ genotype + (1|mouse))
inflammation = continuous dependent variable
genotype = categorical independent variable (binary), fixed effects
mouse = arbitrary number, random effects
Does this sound right to you?