2
$\begingroup$

Use X ray to hit the DNA, and DNA breaks (double strand breaks, DSBs). I'd assume the distribution of number of DSBs at a particular location on DNA is poisson? Or negative binomial?

How can I obtain the parameters (lambda, p, etc.) and how can I test if the data fall into what distribution?

The raw count histogram looks like the following:

enter image description here

The log(count) histogram looks like the following:

enter image description here

The distribution of the raw count:

1   209352
2   89918
3   32137
4   12316
5   5660
6   3060
7   1813
8   1102
9   781
10  535
11  364
12  331

.....

$\endgroup$
2
  • 1
    $\begingroup$ It is obviously not Poisson, as in the case of Poisson mean = variance. $\endgroup$
    – Tim
    Nov 16, 2016 at 14:43
  • $\begingroup$ Why do you think mean != variance here? Thanks. $\endgroup$ Nov 17, 2016 at 14:01

0

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service and acknowledge you have read our privacy policy.