I have some data I would like to look at to investigate associations between specific TLR genotypes (wild type, heterozygous, homozygous) and both a binary outcome variable (death) and continues (biomarkers).

Would an ordinal logistic regression be appropriate here? Or separate logistic models between the wild type and homozygous, and wild type and heterozygous?

When I look at covariates- do i look at associations with TLR or associations with outcome?

  • $\begingroup$ The death variable doesn't look like ordinal to me. $\endgroup$ – SmallChess Feb 2 '17 at 23:34
  • $\begingroup$ what test should i use to account for the allele frequencies? $\endgroup$ – Lucy Feb 4 '17 at 0:56
  • $\begingroup$ You have a continuous and a nominal variable. Why can't you just use a simple logistic regression? $\endgroup$ – SmallChess Feb 4 '17 at 3:03
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    $\begingroup$ Are the continuous biomarkers also to be used as predictors of death? Do you have information about time to death? $\endgroup$ – EdM Feb 4 '17 at 10:36
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    $\begingroup$ Please look at this thread for background. "Ordinal logistic regression" typically means having an ordinal response variable; here you have binary outcome and ordinal predictor. $\endgroup$ – EdM Feb 4 '17 at 10:49

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