I do not have any experience doing statistics with data from a meta-analysis. However, I am working on a research project at the moment where I must look for a significant difference between groups in the meta-analysis. But my project advisor is off at the moment and I would like to begin this part of the project before he returns. So, I was wondering if someone with experience doing meta-analyses can help me?
There are 3 groups in this meta-analysis (group A,B and C). Each group has a different population and different number of people in each group. Each study in the meta-analysis gives me a proportion of individuals with Thyroid cancer for each group (A,B and C). I would like to find if there is a significant difference in prevalence of Thyroid cancer between the 3 groups. I am a bit confused about how to do this? Do I use a T-test to find the sig. difference in each individual study? Do I find the weighted average of the proportions in each group (ie averaging out the proportions for each study in each of the 3 groups) and then do the t-test? Would it be best to use another statistical test?
@mdewey I have about 50 studies in the meta-analysis. Not all of them use the exact same 3 groups. Some only use one of the groups and others use all 3 (none of them use 2 groups). I have the proportions for each study and group in the study. For example, if a study has 3 groups, then I will have a proportion for each of the groups. I would like to find out if there's an overall significant difference in proportions between the 3 groups.