I have non-normal data which are sampled from roughly 4 subjects at 4 dose levels. Is there a nonparametric test for trend I can use in SAS?

  • $\begingroup$ SAS' NPAR1WAY procedure is your best bet. Commonly used nonparametric tests for trend include the Mann-Whitney and the Wilcoxon tests. Here's a link to the SAS support description... support.sas.com/rnd/app/stat/procedures/… $\endgroup$ – Mike Hunter Mar 10 '17 at 20:35
  • $\begingroup$ Are you trying to perform an ANOVA type analysis where you want a trend alternative (e.g. like $\mu_4\geq \mu_3\geq\mu_2\geq\mu_1$ with at least one strict inequality)? Are you treating the subjects as blocks or as random effects? $\endgroup$ – Glen_b Mar 11 '17 at 23:59
  • $\begingroup$ I want something approaching testing whether the slope > 0 as the dose gets higher. I would treat the subjects as random effects. $\endgroup$ – Bosley Mar 13 '17 at 17:15

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