# bootstrap method

I'd like to ask you something about the bootstrap method. If I understood correctly, I can use this method when the size of a sample is small, in order to extract more information. For example, applying a Cox model I noticed that when I had a bigger sample (n=1050), I found several significant small effects and a big significant effect for only one variable. When I reduced the sample size (n=300), all small effects disappeared, remaining only the variable with big effect as significant variable. Can I use a bootstrap method on this sample (n=321) and realize many Cox models (for example generating 1000 samples) in order to make stronger the effects of the variables with small effects?

It has also nothing to do with making insignificant effects significant! When using bootstrap, you sample with replacement $N$ observations out of sample of size $N$, you do not sample more or less observations than you have seen initially. If you sampled more values then you had initially, you would possibly hack the $p$-values, in fact if you sampled a huge number of observations from your data you may find that every effect in your dataset to be "significant", since $p$-values depend on sample size. So if your aim is to lie with statistics, then this is a very easy and effective way of hacking your $p$-values.