I need some help as a reviewer is giving me a hard time with the statistics...
I have 2 groups (A and B) where A has received a certain intraoperative treatment and B has not.
Now I measure pain postoperatively using numeric rating scales (from 1 to 10) at 5 different time points in the postoperative course.
I am actually interested in the comparison of the mean NRS scores between the two groups at each individual time point and I am not interested in comparing the values over time (e.g. timepoint 1 versus timepoint 5).
So I have used Wilcoxon signed rank test.
Now the reviewer states the following (I apologize for the capital letters but that is how I received the comment):
"THIS IS NOT THE CORRECT STATISTICAL ANALYSIS SINCE AN ANOVA FOR REPEATED MEASURES HAS TO BE CARRIED OUT, MAYBE CONSIDERING ALSO SOME TRANSFORMATION OF THE VARIABLES. THE CONSIDERED TEST COMPARED THE SAME GROUP AT TWO TIME POINTS (TWO REPEATED MEASURES) AND IN THIS CASE, WE HAVE TWO GROUPS OF RANDOMIZED PATIENTS AND FIVE TIME POINTS."
Is he wrong or do I not get it? Is it considered a repeated measure even if I am only interested in the pairwise comparison at each time-point and not in a comparison of different time points?
How should I respond?