I am attempting to determine the sample size needed in a clinical study of 2 treatment groups to one control group (3 groups total). However, I am not sure how to calculate this properly. Traditionally, the
bsamsize function in the
Hmisc package is what I have been using to calculate sample size if the desired power, proportions of each group being compared (p0 under null and p1 under alternative), and the fraction of observations in the first group. You can find this function's documentation here: https://www.rdocumentation.org/packages/Hmisc/versions/4.1-0/topics/bpower
So I am wondering, how would one go about calculating the sample size needed for, say, 2 treatment groups and 1 control group, if one wanted equal numbers of subjects in each group? In this case, I don't think there is a way to do this using the
bsamsize function, since this assumes only one hypothesis being tested. How would I want to go about specifying multiple hypotheses (e.g., Control mean is different from Treatment 1 but not Treatment 2, Control mean is different from both Treatment 1 and Treatment 2, etc.)?
So far, I have tried the following code using generic values:
p1 = 0.1 p2 = 0.15 frac = 1/3 bsamsize(p1, p2, fraction=frac, alpha=.05, power=.8)
To get the output:
n1 n2 525.3318 1050.6636
I believe that the fraction needs to be 1/3 if I have 3 groups total. But, when using this function, we can only specify p1 and p2, and not a third proportion, say p3, to get 3 equal sample sizes for 3 total groups.
I am hoping that someone knows of a package that can handle a research question such as this. I also would be interested to know how to generalize this problem, say to compare 3, 4, 5, ..., x treatments to a control at once.
Thank you for any/all help!