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I have 250 subjects, divided in three groups (different medical conditions).

For each subject I have concentrations from three 'areas' (nested) at 5 timepoints.

subject 1, condition A, area X, timepoint 1, concentration *
subject 1, condition A, area X, timepoint 2, concentration *
etc
subject 1, condition A, area Y, timepoint 1, concentration *
subject 1, condition A, area Y, timepoint 2, concentration *
etc
subject 2, condition B, area X, timepoint 1, concentration *
etc etc etc

I'm interested in concentration changes over time and differences between groups (medical conditions), how best to approach this?

I'm a dummy, so please explain as simple as possible, preferably with SPSS :)

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1 Answer 1

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Repeated measures ANOVA, with condition and area as between-subject variables, and timepoint as within-subject variable

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  • $\begingroup$ Thank you! That seems much easier than initially thought. Why a repeated measure ANOVA rather than a mixed model? I thought concentration is nested within area is nested within condition/subject? And would it change if I have some missing data? $\endgroup$
    – Susan
    Apr 23, 2018 at 13:20

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