# Either quadratic or interaction term is significant in isolation, but neither are together

As part of an assignment, I had to fit a model with two predictor variables. I then had to draw a plot of the models' residuals against one of the included predictors and make changes based on that. The plot showed a curvilinear trend and so I included a quadratic term for that predictor. The new model showed the quadratic term to be significant. All good so far.

However, the data suggest that an interaction makes sense, too. Adding an interaction term to the original model also 'fixed' the curvilinear trend and was also significant when added to the model (without the quadratic term). The problem is, when both the quadratic and the interaction term are added to the model, one of them is not significant.

Which term (the quadratic or the interaction) should I include in the model and why?

### Synopsis

When the predictors are correlated, a quadratic term and an interaction term will carry similar information. This can cause either the quadratic model or the interaction model to be significant; but when both terms are included, because they are so similar neither may be significant. Standard diagnostics for multicollinearity, such as VIF, may fail to detect any of this. Even a diagnostic plot, specifically designed to detect the effect of using a quadratic model in place of interaction, may fail to determine which model is best.

### Analysis

The thrust of this analysis, and its main strength, is to characterize situations like that described in the question. With such a characterization available it's then an easy task to simulate data that behave accordingly.

Consider two predictors $X_1$ and $X_2$ (which we will automatically standardize so that each has unit variance in the dataset) and suppose the random response $Y$ is determined by these predictors and their interaction plus independent random error:

$$Y = \beta_1 X_1 + \beta_2 X_2 + \beta_{1,2} X_1 X_2 + \varepsilon.$$

In many cases predictors are correlated. The dataset might look like this: These sample data were generated with $\beta_1=\beta_2=1$ and $\beta_{1,2}=0.1$. The correlation between $X_1$ and $X_2$ is $0.85$.

This doesn't necessarily mean we are thinking of $X_1$ and $X_2$ as realizations of random variables: it can include the situation where both $X_1$ and $X_2$ are settings in a designed experiment, but for some reason these settings are not orthogonal.

Regardless of how the correlation arises, one good way to describe it is in terms of how much the predictors differ from their average, $X_0 = (X_1+X_2)/2$. These differences will be fairly small (in the sense that their variance is less than $1$); the greater the correlation between $X_1$ and $X_2$, the smaller these differences will be. Writing, then, $X_1 = X_0 + \delta_1$ and $X_2 = X_0 + \delta_2$, we can re-express (say) $X_2$ in terms of $X_1$ as $X_2 = X_1 + (\delta_2-\delta_1)$. Plugging this into the interaction term only, the model is

\eqalign{ Y &= \beta_1 X_1+ \beta_2 X_2 + \beta_{1,2}X_1(X_1+ [\delta_2-\delta_1]) + \varepsilon \\ &= (\beta_1 + \beta_{1,2}[\delta_2-\delta_1]) X_1+ \beta_2 X_2 + \beta_{1,2}X_1^2 + \varepsilon }

Provided the values of $\beta_{1,2}[\delta_2-\delta_1]$ vary only a little bit compared to $\beta_1$, we can gather this variation with the true random terms, writing

$$Y = \beta_1 X_1+ \beta_2 X_2 + \beta_{1,2}X_1^2 + \left(\varepsilon +\beta_{1,2}[\delta_2-\delta_1] X_1\right)$$

Thus, if we regress $Y$ against $X_1, X_2$, and $X_1^2$, we will be making an error: the variation in the residuals will depend on $X_1$ (that is, it will be heteroscedastic). This can be seen with a simple variance calculation:

$$\text{var}\left(\varepsilon +\beta_{1,2}[\delta_2-\delta_1] X_1\right) = \text{var}(\varepsilon) + \left[\beta_{1,2}^2\text{var}(\delta_2-\delta_1)\right]X_1^2.$$

However, if the typical variation in $\varepsilon$ substantially exceeds the typical variation in $\beta_{1,2}[\delta_2-\delta_1] X_1$, that heteroscedasticity will be so low as to be undetectable (and should yield a fine model). (As shown below, one way to look for this violation of regression assumptions is to plot the absolute value of the residuals against the absolute value of $X_1$--remembering first to standardize $X_1$ if necessary.) This is the characterization we were seeking.

Remembering that $X_1$ and $X_2$ were assumed to be standardized to unit variance, this implies the variance of $\delta_2-\delta_1$ will be relatively small. To reproduce the observed behavior, then, it should suffice to pick a small absolute value for $\beta_{1,2}$, but make it large enough (or use a large enough dataset) so that it will be significant.

In short, when the predictors are correlated and the interaction is small but not too small, a quadratic term (in either predictor alone) and an interaction term will be individually significant but confounded with each other. Statistical methods alone are unlikely to help us decide which is better to use.

### Example

Let's check this out with the sample data by fitting several models. Recall that $\beta_{1,2}$ was set to $0.1$ when simulating these data. Although that is small (the quadratic behavior is not even visible in the previous scatterplots), with $150$ data points we have a chance of detecting it.

            Estimate Std. Error t value Pr(>|t|)
(Intercept)  0.03363    0.03046   1.104  0.27130
x1           0.92188    0.04081  22.592  < 2e-16 ***
x2           1.05208    0.04085  25.756  < 2e-16 ***
I(x1^2)      0.06776    0.02157   3.141  0.00204 **

Residual standard error: 0.2651 on 146 degrees of freedom
Multiple R-squared: 0.9812, Adjusted R-squared: 0.9808


The quadratic term is significant. Its coefficient, $0.068$, underestimates $\beta_{1,2}=0.1$, but it's of the right size and right sign. As a check for multicollinearity (correlation among the predictors) we compute the variance inflation factors (VIF):

      x1       x2  I(x1^2)
3.531167 3.538512 1.009199


Any value less than $5$ is usually considered just fine. These are not alarming.

Next, the model with an interaction but no quadratic term:

            Estimate Std. Error t value Pr(>|t|)
(Intercept)  0.02887    0.02975    0.97 0.333420
x1           0.93157    0.04036   23.08  < 2e-16 ***
x2           1.04580    0.04039   25.89  < 2e-16 ***
x1:x2        0.08581    0.02451    3.50 0.000617 ***

Residual standard error: 0.2631 on 146 degrees of freedom
Multiple R-squared: 0.9815, Adjusted R-squared: 0.9811

x1       x2    x1:x2
3.506569 3.512599 1.004566


All the results are similar to the previous ones. Both are about equally good (with a very tiny advantage to the interaction model).

Finally, let's include both the interaction and quadratic terms:

            Estimate Std. Error t value Pr(>|t|)
(Intercept)  0.02572    0.03074   0.837    0.404
x1           0.92911    0.04088  22.729   <2e-16 ***
x2           1.04771    0.04075  25.710   <2e-16 ***
I(x1^2)      0.01677    0.03926   0.427    0.670
x1:x2        0.06973    0.04495   1.551    0.123

Residual standard error: 0.2638 on 145 degrees of freedom
Multiple R-squared: 0.9815, Adjusted R-squared: 0.981

x1       x2  I(x1^2)    x1:x2
3.577700 3.555465 3.374533 3.359040


Now, neither the quadratic term nor the interaction term are significant, because each is trying to estimate a part of the interaction in the model. Another way to see this is that nothing was gained (in terms of reducing the residual standard error) when adding the quadratic term to the interaction model or when adding the interaction term to the quadratic model. It is noteworthy that the VIFs do not detect this situation: although the fundamental explanation for what we have seen is the slight collinearity between $X_1$ and $X_2$, which induces a collinearity between $X_1^2$ and $X_1 X_2$, neither is large enough to raise flags.

If we had tried to detect the heteroscedasticity in the quadratic model (the first one), we would be disappointed: In the loess smooth of this scatterplot there is ever so faint a hint that the sizes of the residuals increase with $|X_1|$, but nobody would take this hint seriously.

What makes the most sense based on the source of the data?

We cannot answer this question for you, the computer cannot answer this question for you. The reason that we still need statisticians instead of just statistical programs is because of questions like this. Statistics is about more than just crunching the numbers, it is about understanding the question and the source of the data and being able to make decisions based on the science and background and other information outside the data that the computer looks at. Your teacher is probably hoping that you will contemplate this as part of the assignment. If I had assigned a problem like this (and I have before) I would be more interested in the justification of your answer than which you actually chose.

It is probably beyond your current class, but one approach if there is not a clear scientific reason for prefering one model over the other is model averaging, you fit both models (and maybe several other models as well), then you average together the predictions (often weighted by the goodness of fit of the different models).

Another option, when possible, is to collect more data and if possible choosing the x values so that it becomes more clear what the non-linear vs. interaction effects are.

There are some tools for comparing the fit of non-nested models (AIC, BIC, etc.), but for this case they probably will not show enough difference to overrule understanding of where the data comes from and what makes the most sense.

Yet another possibility, in addition to @Greg's is to include both terms, even though one is not significant. Including only statistically significant terms is not a law of the universe.

• Thanks Peter & @Greg. I guess that at this stage of my studies I'm looking for absolute answers to questions that need at least some qualitative reasoning. Since the addition of either the quadratic term or the interaction term 'fixed' the residuals vs predictor plot, I was not sure which one should be included. What did surprise me is that the inclusion of a quadratic term rendered the interaction term non-significant. I would have thought that if there is an interaction, it would be significant regardless of whether a quadratic term was included or not. – Tal Bashan Aug 17 '12 at 7:54
• Hi @TalBashan A famous statistician, Donald Cox, once said that "there are no routine statistical questions, only questionable statistical routines" – Peter Flom Aug 17 '12 at 8:57
• @PeterFlom Maybe you mean Sir David Cox?? – Michael R. Chernick Aug 17 '12 at 16:51
• Ooops. Yes, David, not Donald. Sorry. – Peter Flom Aug 17 '12 at 17:03