# Main effect insignificant: should I estimate an interaction with it?

As the title reveals, does it make sense to estimate an interaction when you already see that a main effect is insignificantly different from 0 in regression?

In my study I am actually interested in this interaction, as its part of my research question. Can I conclude the interaction will be insignificant too, or can it happen that the interaction will be significant? I usually only estimate interactions when the main effects are significant, hence I am asking/unsure.