# Use samples from each individual or pool samples from several individuals.

I have a system that can predict that can predict the blood pressure for hospitalized patients from zero to 120 minutes into the future. Now I want to see if my predictions are statistically significant. So I want to investigate how well my predictions correlate with the real value. I have twenty patients with varying amount of samples, due to different duration of the hospitalization. My problem is that I don't know if I should pool all samples across all the patients or should I only pool one patient's samples at a time. My intuition tells me that I shouldn't pool all samples since patients that have high values also tend to have high errors and patients with more samples will weight more than other patients.

My strategy has been the following so far: For each patient, I take his/her samples and use the Shapiro Wilks test to test for normality. The results tells me that they are not normal distributed. Then i use the Spearman Rho test and this gives me a p-value and confidence intervals. All patient's except one is significant. So can i take the mean of the p-values, or? I am not confident in my approach. But is this a way to go?

• No to the mean of the p-values. Do you mean each time when the patient blood pressure is measured, you also produced a predicted blood pressure, so data are kind of paired (measured, predicted) blood pressure? – user158565 Dec 9 '18 at 3:14
• Yes. For example, at time 21:00 we predict the blood pressure for the time 01:00. Then we measure the actual blood pressure at time 01:00. Then we can compare the actual with the predicted value. But there is a big age span, and patients may have different diseases(like diabetes 1 or 2, etc.), so the magnitude and variation of blood pressure differs between patients and my biggest concern is that some patients have maybe 20 samples, others have 300. – Xraycat922 Dec 9 '18 at 8:55