I need help with meta-analysis
Description- we have two types of medical treatments- A & B across multiple trials. I'm trying to calculate cumulative odds ratio of an adverse event happening after treatment A & B. However, with treatment A, the adverse event is HIGHER after treatment while with treatment B, the adverse event is LOWER after treatment. when I try using revman trying to calculate odds ratio, it would not obviously let me as there can be no negative number. FYI A & B are both treatments - no control.
Goal- to show that treatment A worsens the adverse events compared to treatment B in a meta- analysis/ANY PERTINENT STATISTICAL TEST
I would like to know if there is any other effect size/ measurement that I could calculate so that I can resolve this issue.
rephrasing the question- how to compare two interventions when one treatment improves an outcome while other worsens it?
Thanks in advance VP