I am aware of that multiple testing correction is needed when multiple hypothesis tests are simultaneously performed. However, I am a little confused by the word "simultaneously".
Say I have hundereds of samples and I derived multiple features (variables) from each sample. With this sample-feature matrix, I would like to perform pairwise fisher exact test for feature co-occurrence. Do I need to carry out multiple testing correction on the P-value of each paired feature?
I guess multiple testing correction is needed. However, I can consider that each of the pairwise fisher exact test was carried out individually and each raw p-value represents the significance of correponding paired features, right?