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I am currently looking at continuous data and seeking a correlation with the presence (and severity, ie, normal, mild, moderate, severe) of a disease entity. Now, so far, running Spearman on SPSS, I've gotten an R of 0.370, p<0.001.

I need help on a couple of things. Can/Should I perform a multinomial regression analysis? Also, I'd like to generate a ROC and find out corresponding cut-off values that may pertain to the severity of the disease, i.e., Normal, Mild, Moderate, Severe.

Please advise on how to go about this. Any input is highly appreciated.

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  • $\begingroup$ Welcome to the site. What is/are your dependent and independent variables (if any)? Regression analysis is for relating a DV to one or more IVs. Multinomial is appropriate if the DV is categorical with more than 2 categories that are not ordered. That doesn't sound like the case you are dealing with. Why are you trying to find cut-off values? Categorizing a continuous variable is rarely a good idea. $\endgroup$
    – Peter Flom
    Oct 30 '12 at 10:55
  • $\begingroup$ Thanks for the reply, @Peter! The DV is the disease. It is subcategorized into its severity, ie 0-normal, 1-mild, 2-moderate, 3-severe. I am trying to find cut-off values because my hypothesis is the bigger my IV is (which is a unit of measurement), the more severe my DV category is. I'd like to arrive at something like <3 is normal, 4-5 is mild, 6-7 moderate, >7 severe. $\endgroup$
    – ome
    Oct 30 '12 at 11:15
  • $\begingroup$ If your independent variable is continuous, there is no need to categorize it. You can do ordinal logistic regression with an ordinal DV (disease) and a continuous IV. $\endgroup$
    – Peter Flom
    Oct 30 '12 at 11:28
  • $\begingroup$ I see. Now, can I proceed with ROC analysis? If yes, do I use the real values or do I use the predicted probabilities? I apologize, I'm really confused. $\endgroup$
    – ome
    Oct 30 '12 at 11:59
  • $\begingroup$ You should be able to generate something at least similar to an ROC curve from those results. What software are you using? $\endgroup$
    – Peter Flom
    Oct 30 '12 at 12:04

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