# Parameter Estimation in Generalized Linear Mixed Models

Let us assume a generalized linear mixed model with a binary dependent variable $$y_{i, t }$$ that is explained by a fixed effect matrix X and a simple random intercept for each individual $$i$$

$$y_{i,t} = x_{i,t}'\beta +\alpha_i + \epsilon_{i,t} \hspace{35pt} \alpha \sim N(0, \sigma_{\alpha})$$

As far as I know, when we want to estimate the fixed and random effects via maximum likelihood, we have to integrate out the random effects over every individual so that the log likelihood becomes

$$LL(\beta) = \sum_{i=1}^N \log \left(\int_{-\infty}^{\infty} \prod_{t=1}^{T_i}F(y_{i,t}|\alpha_i, \beta) g(\alpha_i) d \alpha_i \right)$$

However, if we integrate the random intercepts out, the $$\alpha$$ disappears and we can only solve for $$\beta$$. How do we estimate $$\alpha$$ then?

• The parameters of your model are $(\beta, \sigma_\alpha)$ and not $(\beta,\alpha)$. The integrals over the random effects are function of both $\beta$ and $\sigma_\alpha$. – winperikle Jul 12 at 14:00
• Thank you for your quick reply. You are right, the random intercepts are not parameters. But still they take on values, right? How do we determine those values? – Benkyozamurai Jul 12 at 15:41
• The model should be $y_{i,t} = x_{i,t}'\beta +\alpha_i + \epsilon_{i,t} \hspace{35pt} \alpha_i \sim N(0, \sigma_{\alpha}) \hspace{35pt} \epsilon_{i,t} \sim N(0, \sigma)$ and $\epsilon_{i,t}$ and $\alpha_i$ are independent. – user158565 Jul 12 at 17:14

When you have a binary outcome variable you typically use a link function to connect the probability of a positive response to the linear predictor that includes the random effects, i.e., $$\begin{equation} \left \{ \begin{array}{l} \log \displaystyle \frac{\pi_{it}}{1 - \pi_{it}} = x_{it}^\top \beta + z_{ij}^\top b_i,\\\\ \pi_{it} = \Pr(y_{it} = 1 \mid b_i),\\\\ b_i \sim \mathcal N(0, D), \end{array} \right. \end{equation}$$ where $$x_{it}$$ is a design vector for the fixed effects coefficients $$\beta$$, and $$z_{it}$$ a design vector for the random effects $$b_i$$.
When you fit the model under maximum likelihood, the random effects are unobserved variables that are integrated out from the expression of the log-likelihood of the model, i.e., $$\ell(\theta) = \sum_{i = 1}^n \log \int \prod_t p(y_{it} \mid b_i; \beta) \; p(b_i; D) \; db_i,$$ where $$\theta^\top = (\beta^\top, \mbox{vech}(D))$$ denotes the parameters of the model. The integral does not have a closed-form solution, and is typically approximated using either the Laplace approximation or adaptive Gaussian quadrature (the latter is considered better).
The random effects are estimated in a second step using empirical Bayes methodology, that is, for $$i = 1, \ldots, n$$ they are estimated as the modes of the posterior distribution $$p(b_i \mid y_i) \propto p(y_i \mid b_i; \hat \beta) \; p(b_i; \hat D),$$ where $$\hat \beta$$ and $$\hat D$$ denote the maximum likelihood estimates of $$\beta$$ and $$D$$, respectively.