Irregularly spaced time-series in finance/economics research In financial econometrics research, it is very common to investigate relationships between financial time series that take the form of daily data. The variable will often be made $I(0)$ by taking the log difference, for example; $\ln(P_t)-\ln(P_{t-1})$. 
However, daily data means that there's $5$ data points each week, and Saturday and Sunday are missing. This seems to get no mention in the applied literature that I'm aware of. Here's some closely related questions that I have that come from this observation:


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*Does this qualify as irregularly spaced data, even though financial markets are closed over the weekend?

*If so, what are the consequences for the validity of extant empirical results garnered thus far in the gigantic number of papers that ignore this issue? 
 A: Full disclosure! I don't know about finance/economy, so sorry in advance for my ignorance. But I find this question wider than finance. Analyzing irregularly sampled data arises in many other fields, such as biology and medicine. One of the shortcomings of classical approaches like Autoregressive Regression (AR) is their weakness in dealing with irregularly sampled data. However this problem can be tackled by Gaussian processes (GPs). It's used for example here or here. 
A: Traditionally, we don't worry about non trading days and count this as regularly spaced data.  There are however two possible effects that you'd have to worry about.   
The first is the effect of time on momentum and interaction with leading indicators.   If you have a lagged variable that is a good leader - let's say it's mean temperature - then some of your data points will be lagged to the next day (Friday -> Thurs) while others are lagged three days (Monday -> Friday).  There's likely to be spurious results because of that. 
The second issue is activity that happens when markets are closed.  After hours trading, options pricing, etc.   If those are a factor, you may be better off calculating a regularly spaced time series and interpolating or accounting for non-trading days some other way.
