There are multiple things you can do. I would recommend looking at the problem from the perspective of the new causal revolution. You are interested in the causal effect of $\{A,B,C,D,E,FF,G\}$ on $Y,$ but you're unsure if there are causal relationships among the explanatory variables. The very first thing I would do is draw a causal diagram. This is just a Directed Acyclic Graph (DAG), where node $A$ causing node $B$ is represented by the simple arrow $A\to B.$ NEVER underestimate the power of a DAG in analyzing cause-and-effect. Once you have your DAG, you can start to think about what would make the most sense to do, to isolate the causal effect in which you're interested. For example: suppose you have the following DAG:
This is called a mediation scenario. You do NOT have a back-door path from $X$ through $Z$ to $Y,$ because the arrow between $X$ and $Z$ points to $Z.$ This is therefore not a confounding situation, even though $X$ and $Z$ would likely be correlated. There is no need to condition on $Z.$ In fact, if you want the true causal effect of $X$ on $Y,$ you should NOT condition on $Z.$ On the other hand, suppose you had this situation:
Now you have a backdoor path: $X\leftarrow Z\to Y,$ and you must condition on $Z.$
Now I've used this term "conditioning" a couple of times. In a linear regression scenario, conditioning looks like simply including the variable in the model. So in the mediation example (the first one above), not conditioning on $Z$ means your model is $Y=mX+b.$ In the confounding example (the second one with the backdoor path), conditioning on $Z$ means your model is $Y=mX+nZ+b.$
This should get you started, I hope. If you draw a DAG for your situation, please do include it in your question.