# Limit of quantile normalization

Is quantile normalization adequate for normalizing data with very few samples?

For example this microarray data. Typically after normalization we'd like to compare Cancer-1 with Normal and Cancer-2 with Normal for differential expression.

    mRNA     Cancer-Type-1   Cancer-Type-2  Normal
-----------------------------------------------------------
mRNA1      30        49    12
mRNA2     199        200   78
...        ...       ...  ....
mRNA1000   13        40    88


If not what is the appropriate normalization method?