Suppose my sample comprises 350 instances. Each instance has two independent binary (
neg) evaluations, A and B. If my alternative hypothesis is that A is more often positive than B, how would I express whether the difference is statistically significant?
To be more precise on the data: This question came to mind when looking at patient blood serum data. These are 350 blood samples positive against X. Each sample may or may not also be positive against A or B, whereas A and B are both more often positive if X is positive, but biologically are not dependent on one another.
So my initial thought was to look whether A is more often positive than B. In the example it was, A is positive in ~80% and B in ~20%. So I thought about assessing this difference for significance and this is where I got stuck. :)