I search a detailed proof of the multivariate Cramer-Rao inequality in the general case where the estimator is not necessarily unbiased.
Let $T(X)$ be an estimator of the parameter $\theta\in\mathbb{R}^m$. Let $\psi$ be the expectation of $T(X)$: \begin{align} \psi(\theta) = \mathbb{E}(T(X)) \end{align} for any $\theta\in\mathbb{R}^m$. Assume that the following regularity condition holds: \begin{align} \frac{\partial }{\partial \theta} \int_{\mathbb{R}^n} T(x) f(x ; \theta) dx = \int_{\mathbb{R}^n} \frac{\partial }{\partial \theta} T(x) f(x ; \theta) dx \end{align} for any $\theta\in\mathbb{R}^m$. If $\psi$ is differentiable, therefore, \begin{align} \mathbf{Cov}(T(X)) \geq \left[ \frac{\partial \psi(\theta)}{\partial \theta} \right]^T [I(\theta)]^{-1} \left[ \frac{\partial \psi(\theta)}{\partial \theta} \right] \end{align} for any $\theta\in\mathbb{R}^m$.
The Cramer-Rao inequality is a matrix inequality. If $A$ and $B$ are two real square matrices, we say that $A \geq B$ if the matrix $A - B$ is positive definite. The matrix $\frac{\partial \psi(\theta)}{\partial \theta}$ is the Jacobian matrix of $\psi$: $$ \left(\frac{\partial \psi(\theta)}{\partial \theta}\right)_{ij} = \frac{\partial \psi(\theta)_i}{\partial \theta_j} $$ for $i,j = 1, \ldots, m$.
Let $s$ be the score function, i.e. the gradient vector of the log-likelihood. It is not very difficult to see that: $$ \mathbf{Cov}(s_j(\theta),T(X)) = \frac{\partial \psi(\theta)_i}{\partial \theta_j} $$ for $j=1,\ldots, m$. The previous equation can be obtained based on the straightforward differentiation of the log-likelihood, the regularity condition and the definition of $\psi$. At this point, the univariate proof uses the Cauchy-Schwartz probabilistic inequality, but this cannot be used in the multivariate case. How to conclude?
Indeed, the univariate proof is not too difficult, but the multivariate proof is more tricky. In Jun Shao "Mathematical Statistics", p.169, the proof is "left to the reader"...