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I ran a mediation analysis with two mediators (M1 and M2) using lavaan and I am somehow confused about the results:


Direct Effect: The total direct effect of X on Y is not significant. X is, however, significantly related to M1 and M1 is significantly related to Y. As for M2, no significant direct relationships are observed.

Indirect Effect: The indirect effect of X on Y through M1 is not significant. The same also applies to M2.

Total Indirect Effect: When adding the two indirect effects, a significant result is shown. How is that possible?

Total Effect: The total effect is not significant.


I am mostly confused about the Total Indirect Effect. How can it be significant when the two indirect effects are not?

It might be useful to add that I let M1 and M2 covary. Could this serve as an explanation?

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  • $\begingroup$ "I let M1 and M2 covary. Could this serve as an explanation?" No. $\endgroup$ Commented Dec 28, 2020 at 20:05
  • $\begingroup$ The total indirect effect is a bit like a multivariate test, where the individual effects are univariate tests. They should not be expected to agree. You picked a threshold (presumably 0.05). Pick a different threshold and this won't be true. $\endgroup$ Commented Dec 28, 2020 at 20:06

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The total indirect effect is actually the sum of all specific indirect effects, or, more simply the total effect between $X$ and $Y$ less the direct effect between $X$ and $Y$. You can obtain barely significant specific indirect effects (which I guess happened) and when you add them up, it can reach the significance threshold.

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  • $\begingroup$ Are you aware of any references that explain this further? $\endgroup$ Commented Jun 13, 2022 at 18:00
  • $\begingroup$ @canderson156 A place to start : tqmp.org/RegularArticles/vol18-1/p066 $\endgroup$
    – POC
    Commented Jun 15, 2022 at 12:52

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