Research question: What is the optimal cut-off value for a continuous covariate (age) with a binary outcome (suitable or not for a certain treatment). I realize that we lose information by dichotomizing the variable but we the aim is to use this cut-off value in clinic.

I intended to use ROC curve analysis or logistic regression. What would you recommend or do you have any other suggestions?

Thank you in advance.

  • $\begingroup$ Don't bin your continuous data. Feed them into your algorithm as-is; potentially transform them using (e.g.) restricted cubic splines (see, e.g., Frank Harrell's Regression Modeling Strategies) to capture any nonlinearity. $\endgroup$ Feb 24, 2021 at 14:59
  • $\begingroup$ See this and this $\endgroup$
    – John L
    Feb 24, 2021 at 21:06


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