How is this equation derived? thanks
RR=OR/((1−Pref)+(Pref∗OR))
RR = risk ratio; OR = odds ratio; Pref = Prevalence of the outcome in the reference group
Relative Risk
RR = p1/p0
Odds Ratio
OR = (p1/(1-p1)) * ((1-p0)/p0)
OR * (p0/(1-p0)) = p1/(1-p1)
(1-p0)/(OR*p0) = (1-p1)/p1
(1-p0)/(OR*p0) = 1/p1 - 1
1 + (1-p0)/(OR*p0) = 1/p1
(OR*p0+(1-p0))/(OR*p0) = 1/p1
(OR*p0)/(OR*p0+(1-p0)) = p1
p1 = (OR*p0)/(OR*p0+(1-p0))
Since RR = p1/p0
p1 = (OR*p0)/(OR*p0+(1-p0))
p1/p0 = (OR*p0)/((OR*p0+(1-p0))*p0)
p1/p0 = OR / OR*p0+(1-p0)
which means:
RR = OR / ((1-p0)+(OR*p0))
RR = risk ratio; OR = odds ratio; p1 = the outcome in the experiment/exposed group; p0 = the outcome in the reference group