0
$\begingroup$

I found the term of "degree of variability" from a academic paper. It seems to be used to determine the cutoff of a continuous variable. The most drastic change point was used as the cutoff. In the picture below, the red line was the so-called degree of variability. I dont know what does it mean and why the inflection point can be used as the cutoff. How to calculate it, any code if possible?

**Reference: Hiromi Nakamura, et al. Genomic spectra of biliary tract cancer. Nature Genetics 2015.**https://www.nature.com/articles/ng.3375#MOESM54

In the legend of the Supplementary Figure S1, it said that "... The most drastic change point in the mutation rate was chosen for the cutoff to discriminate hypermutated cases from non-hypermutated ones."

DistribuCon  of  variability in  mutaCon rate    in  this    cohort. The most    drasCc
change  point   in  the mutaCon rate    was chosen  for the cutof

$\endgroup$
2
  • $\begingroup$ I would use the well known "Change point model" to find the cut-off point. $\endgroup$
    – Amin Shn
    Nov 2 '21 at 9:28
  • $\begingroup$ I don't think this is standard terminology, so it'd help to link the paper (which either should explain how it's defined or give a reference). $\endgroup$ Nov 2 '21 at 9:51

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.