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I have a sparse matrix of representing 12 cancer types. It's a very sparse with about 99% of elements are zeros.

I have a t-SNE looks like:

t

What can I interpret from this t-SNE?

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    $\begingroup$ +1 but you probably need to try another visualization. Visualizations are a bit like jokes, if you need someone to interpret them for you, they aren't working. $\endgroup$
    – usεr11852
    Jun 3, 2022 at 14:41

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So scikit suggests to use TruncatedSCD for sparse data. (Althouh that suggestion is only made when you have a large amount of initial features) https://scikit-learn.org/stable/modules/generated/sklearn.manifold.TSNE.html

It is highly recommended to use another dimensionality reduction method (e.g. PCA for dense data or TruncatedSVD for sparse data) to reduce the number of dimensions to a reasonable amount (e.g. 50) if the number of features is very high.

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