[Context]
@Henry and @JonathanLew firmly pointed out errors in my original answer, which tried to argue that the statement "the exact value of any likelihood is meaningless" is glib and that you can't prove a logical claim about all likelihoods by providing specific examples where it's safe to compute the likelihood up to a constant.
Since I first posted my answer I've learned that continuous likelhoods have (theoretical) units given by 1/(units of the data) from @apdnu's answer to Units for likelihoods and probabilities.
I also searched for concrete examples where likelihood function has to be computed exactly to get the correct answer.
Example #1: Mixture of Bernoullis for latent class analysis
This example is from Chapter 9 of C. M. Bishop. Pattern Recognition and Machine Learning (2006).
We want to model a dataset of binary observations as a mixture of $K$ Bernoulli components with parameters $\{\mu_k\}$ and mixing proportions $\pi_k$. The log likelihood is:
$$
\ln p(\mathbf{X}|\mathbf{\mu},\mathbf{\pi}) =
\sum_{n=1}^N\ln\left\{\sum_{k=1}^K\pi_kp(\mathbf{x}_n|\mathbb{\mu}_k)\right\}
$$
Since there is a summation inside a logarithm, the math doesn't simplify but the maximum likelihood solution can be found with the EM algorithm.
Example #2: Bayesian $t$-test
This example is from Chapter 4 of K. P. Murphy. Machine Learning: A Probabilistic Perspective (2012).
We want to test the hypothesis $\mu > \mu_0$ for some known value of $\mu_0$. The p-value for an one-side t-test is an integral over the likelihood
$$
\begin{aligned}
p(\mu>\mu_0|\text{data}) =
\int_{\mu_0}^\infty p(\mu|\text{data})d\mu
\end{aligned}
$$
We can't omit any terms inside the integral or we won't compute the p-value correctly.
In summary, there are both theory and examples to illustrate that the exact value of the likelihood function can be meaningful.
[Original answer, with corrections following comments]
The statement "the exact value of any likelihood is meaningless" is abstract and imprecise at the same time. So let's start with the definition of likelihood. In the spirit of this question, the definition isn't mathematically rigorous.
We take a probabilistic model f(x,θ) for data x with parameter θ.
- As a function of the data x, f(x,θ) is a probability density/mass function. [pdf if x is continuous; pmf if x is discrete.]
- As a function of the parameter θ, f(x,θ) is the likelihood.
It's true that the likelihood doesn't integrate to 1. Many functions don't, yet we don't conclude that their exact value is meaningless.
- ∫x f(x,θ) dx = 1 [replace the integral with a summation if x is discrete]
- ∫θ f(x,θ) dθ = constant that depends on the model f and the data x
A common theme running through the answers is that likelihood computations often simplify. The logical argument seems to go something like this: in many computations a term in the likelihood is constant or behaves like a constant so we can simplify the math by dropping that term; ergo the exact value of a likelihood function is meaningless.
However, the likelihood has more uses than maximizing it to find the MLE or performing a likelihood ratio test. And a likelihood term that can be ignored in one computation is important to keep track of in another.